منابع مشابه
Reversing cancer stemness
lethality of malignant breast cancer in human patients. Although various targeted and non-targeted therapies can occasionally control the progress of breast cancer, a significant portion of patients develop resistance to chemotherapy and experience metastatic recurrence. The epithelial to mesenchymal transition (EMT), a key developmental program in embryogenesis, has been found to be closely in...
متن کاملKnock out CD44 in reprogrammed liver cancer cell C3A increases CSCs stemness and promotes differentiation.
CD44 is a widely known cancer stem cells marker in various cancers and validated to function in tumor growth, survival and tumor metastasis. In this study, we first established C3A-derived liver cancer stem cells by OSKM method [OCT4, SOX2, KLF4, and c-MYC], termed C3A-induced cancer stem cells (C3A-iCSCs) which acquired self-renewal and stemness abilities. Then we found CD44 was positive in C3...
متن کامل“De-coding” Stemness Pathways in Cancer
Submit Manuscript | http://medcraveonline.com Abbreviations: ncRNAs: Noncoding RNAs; miRs: MicroRNAs; lncRNAs: Long noncoding RNAs; RISC: RNA-Induced-SilencingComplex; mRNAs: Messenger RNAs; CLL: Chronic Lymphocytic Leukemia; RREB1: Ras-Responsive Element-Binding Protein 1; HK2: Hexokinase 2; AldoA: Aldolase A; GPD2: Glycerol-3-phosphate dehydrogenase-2; Xist: X Inactive Specific Transcript; XC...
متن کاملCisplatin induces stemness in ovarian cancer
The mainstay of treatment for ovarian cancer is platinum-based cytotoxic chemotherapy. However, therapeutic resistance and recurrence is a common eventuality for nearly all ovarian cancer patients, resulting in poor median survival. Recurrence is postulated to be driven by a population of self-renewing, therapeutically resistant cancer stem cells (CSCs). A current limitation in CSC studies is t...
متن کاملCancer stemness in Wnt-driven mammary tumorigenesis.
Wnt signaling plays a central role in mammary stem cell (MaSC) homeostasis and in breast cancer. In particular, epigenetic alterations at different members of the Wnt pathway have been identified among triple-negative, basal-like breast cancers. Previously, we developed a mouse model for metaplastic breast adenocarcinoma, a subtype of triple-negative breast cancer, by targeting a hypomorphic mu...
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ژورنال
عنوان ژورنال: Digestive Diseases
سال: 2017
ISSN: 0257-2753,1421-9875
DOI: 10.1159/000456592